[ 26 Jan 2018 | NEWS ] PhD scholarship available in bioinformatics
PhD position in computational biology/bioinformatics
We have a PhD position, including scholarship covering fees and living expenses, available in our group in Auckland, New Zealand. The prospective candidate will analyse transcriptomics and genomics data sets from high-throughput experiments in mammalian systems with a focus on gene regulation and non-coding RNAs. Please have a look at our recent publications to get an idea on what topics we work on. However, if you have specific interests within the wider scope...
[ 24 Oct 2017 | NEWS ] New publication: Epigenetics & Chromatin
We are very happy about this one. The first paper from work led by my PhD student Elena! Congrats! Link to open access article here: https://doi.org/10.1186/s13072-017-0158-9
Macrophages are sentinel cells essential for tissue homeostasis and host defence. Owing to their plasticity, macrophages acquire a range of functional phenotypes in response to microenvironmental stimuli, of which M(IFN-γ) and M(IL-4/IL-13) are well known for their opposing pro- and anti-inflammatory roles. Enhancers have emerged as regulatory DNA elements crucial for...
[ 15 Sep 2017 | NEWS ] New publication: Sci Rep
Our proof-of-principle study of colorectal cancer subtype microbiomes got published today at Scientific Reports. We are currently busy scaling the study up to include many more patients to get a more general picture of the microbiomes of New Zealand colorectal cancer subtypes. In the future we hope we will be able to translate this research into clinical applications. Watch this space!
[ 06 Sep 2017 | BLOG ] A list of journals
After giving the task of choosing the “right” journal for a manuscript to a student, I started to think a bit more about the nature of science publishing. A lot has been written and discussed about predatory publishers/journals and publishers taking advantage of their power over Universities. So, I wanted a list of “good” journals as an initial starting point and guide for students?
I initially thought of two criteria that can be applied to narrow the field...
[ 26 Jul 2017 | NEWS ] Invited guest lecture at the SBS, University of Auckland
Sebastian was invited to the School ol Biological Sciences, University of Auckland, to give a guest lecture on “Epigenome profiling” to 4th year students.
[ 15 Jul 2017 | NEWS ] New preprint: Transcribed macrophage enhancers at bioRxiv.
Background Macrophages are sentinel cells that play essential role in tissue homeostasis and host defence. Owing to their plasticity, macrophages acquire a range of functional phenotypes in response to microenvironmental stimuli, of which M1 (IFNγ) and M2 (IL-4/IL-13) phenotypes are well-known for their opposing pro- and anti-inflammatory roles. Enhancers have emerged as regulatory DNA elements crucial for transcriptional activation of gene expression, with recent studies highlighting their importance in macrophages.
[ 10 Jul 2017 | NEWS ] Invited research seminar at the SBS, University of Auckland
Sebastian was invited to the School ol Biological Sciences, University of Auckland, to give a research seminar. The Seminar talk was entitled: “The regulatory impact of enhancers on macrophage polarization.” Sebastian also met with collaborators to discuss current and future projects.
[ 06 Jul 2017 | NEWS ] New preprint: CRC subtype microbiomes at bioRxiv.
Colorectal cancer (CRC) is a heterogeneous disease and recent advances in subtype classification have successfully stratified the disease using molecular profiling. The contribution of bacterial species to CRC development is increasingly acknowledged, and here, we sought to analyse CRC microbiomes and relate them to tumour consensus molecular subtypes (CMS), in order to better understand the relationship between bacterial species and the molecular mechanisms associated with CRC subtypes....